{"id":10145,"date":"2025-06-12T03:15:51","date_gmt":"2025-06-11T19:15:51","guid":{"rendered":"https:\/\/www.shorro.cn\/index.php\/archives\/10145"},"modified":"2025-06-12T03:15:51","modified_gmt":"2025-06-11T19:15:51","slug":"%e7%a0%94%e7%a9%b6dbu%e5%af%b9%e7%94%b2%e8%8b%af%e7%a3%ba%e9%85%b8%e7%9b%90%e4%bd%9c%e4%b8%ba%e9%80%9a%e7%94%a8%e5%9e%8b%e5%82%ac%e5%8c%96%e5%89%82%e7%9a%84%e9%80%82%e7%94%a8%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.shorro.cn\/index.php\/archives\/10145","title":{"rendered":"\u7814\u7a76DBU\u5bf9\u7532\u82ef\u78fa\u9178\u76d0\u4f5c\u4e3a\u901a\u7528\u578b\u50ac\u5316\u5242\u7684\u9002\u7528\u6027"},"content":{"rendered":"<p><strong>DBU\u5bf9\u78fa\u9178\u76d0\uff1a\u50ac\u5316\u5242\u754c\u7684\u201c\u591a\u9762\u624b\u201d\uff1f<\/strong><\/p>\n<hr \/>\n<p>\u5728\u5316\u5b66\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u90a3\u4e2a\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u633a\u8eab\u800c\u51fa\u7684\u201c\u8d85\u7ea7\u82f1\u96c4\u201d\u3002\u5b83\u4e0d\u53c2\u4e0e\u53cd\u5e94\u672c\u8eab\uff0c\u5374\u80fd\u5927\u5927\u63d0\u5347\u53cd\u5e94\u901f\u7387\u3001\u964d\u4f4e\u80fd\u8017\uff0c\u751a\u81f3\u51b3\u5b9a\u4ea7\u7269\u7684\u9009\u62e9\u6027\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0c<strong>DBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u7684\u5bf9\u78fa\u9178\u76d0<\/strong>\uff0c\u6b63\u9010\u6e10\u5d2d\u9732\u5934\u89d2\uff0c\u6210\u4e3a\u6709\u673a\u5408\u6210\u9886\u57df\u7684\u4e00\u5339\u9ed1\u9a6c\u3002<\/p>\n<p>\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u6765\u804a\u804a\u8fd9\u4e2a\u770b\u4f3c\u4f4e\u8c03\u5374\u6f5c\u529b\u65e0\u9650\u7684\u5316\u5408\u7269\u2014\u2014<strong>DBU\u5bf9\u78fa\u9178\u76d0<\/strong>\uff0c\u770b\u770b\u5b83\u662f\u5426\u771f\u7684\u914d\u5f97\u4e0a\u201c\u901a\u7528\u578b\u50ac\u5316\u5242\u201d\u7684\u540d\u53f7\u3002<\/p>\n<hr \/>\n<h2>\u4e00\u3001DBU\u662f\u8c01\uff1f\u5b83\u7684\u201c\u76d0\u201d\u53c8\u662f\u4ec0\u4e48\uff1f<\/h2>\n<p>\u9996\u5148\uff0c\u6211\u4eec\u5f97\u5148\u8ba4\u8bc6\u4e00\u4e0b\u4e3b\u89d2\uff1a<strong>DBU<\/strong>\u3002<\/p>\n<p>DBU\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u7684\u975e\u4eb2\u6838\u6709\u673a\u78b1\uff0c\u7ed3\u6784\u4e2d\u542b\u6709\u4e24\u4e2a\u6c2e\u539f\u5b50\uff0c\u5448\u73af\u72b6\u6392\u5217\uff0c\u5177\u6709\u5f88\u5f3a\u7684\u78b1\u6027\u548c\u70ed\u7a33\u5b9a\u6027\u3002\u7531\u4e8e\u5176\u5206\u5b50\u7ed3\u6784\u5927\u3001\u4f4d\u963b\u9ad8\uff0cDBU\u4e0d\u50cf\u5e38\u89c1\u7684\u78b1\uff08\u5982NaOH\u6216K\u2082CO\u2083\uff09\u90a3\u6837\u5bb9\u6613\u5f15\u53d1\u526f\u53cd\u5e94\uff0c\u56e0\u6b64\u5728\u8bb8\u591a\u6709\u673a\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u8272\u3002<\/p>\n<p>\u800c<strong>\u5bf9\u78fa\u9178<\/strong>\uff08p-TsOH\uff09\uff0c\u5219\u662f\u4e00\u79cd\u5e38\u7528\u7684\u6709\u673a\u9178\uff0c\u5e7f\u6cdb\u7528\u4e8e\u916f\u5316\u3001\u7f29\u5408\u7b49\u53cd\u5e94\u4e2d\u3002\u5f53DBU\u4e0e\u5bf9\u78fa\u9178\u7ed3\u5408\uff0c\u751f\u6210\u7684\u5c31\u662f<strong>DBU\u5bf9\u78fa\u9178\u76d0<\/strong>\uff0c\u7b80\u79f0<strong>DBU\u00b7TsOH<\/strong>\u3002<\/p>\n<p>\u8fd9\u542c\u8d77\u6765\u6709\u70b9\u50cf\u201c\u5f3a\u5f3a\u8054\u624b\u201d\uff0c\u4e00\u4e2a\u8d1f\u8d23\u78b1\u6027\u50ac\u5316\uff0c\u4e00\u4e2a\u63d0\u4f9b\u9178\u6027\u73af\u5883\uff0c\u4e24\u8005\u7ed3\u5408\u540e\uff0c\u5728\u67d0\u4e9b\u53cd\u5e94\u4e2d\u5c55\u73b0\u51fa\u610f\u60f3\u4e0d\u5230\u7684\u6548\u679c\u3002<\/p>\n<hr \/>\n<h2>\u4e8c\u3001DBU\u00b7TsOH\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u4e00\u89c8<\/h2>\n<p>\u4e3a\u4e86\u8ba9\u5927\u5bb6\u6709\u4e2a\u66f4\u76f4\u89c2\u7684\u8ba4\u8bc6\uff0c\u6211\u6574\u7406\u4e86\u4e00\u5f20\u7b80\u5355\u7684\u8868\u683c\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u6027\u8d28<\/th>\n<th>\u53c2\u6570<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5316\u5b66\u540d\u79f0<\/td>\n<td>DBU\u5bf9\u78fa\u9178\u76d0<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2081\u2087H\u2082\u2085N\u2082O\u2083S<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>\u7ea6337.46 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u81f3\u6de1\u9ec4\u8272\u56fa\u4f53\u7c89\u672b<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u6613\u6eb6\u4e8e\u6c34\u3001\u3001DMF\u3001DMSO\uff1b\u5fae\u6eb6\u4e8e\u3001THF<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>\u7ea6210\u2013215\u00b0C\uff08\u5206\u89e3\uff09<\/td>\n<\/tr>\n<tr>\n<td>pH\u503c\uff081%\u6c34\u6eb6\u6db2\uff09<\/td>\n<td>8.5\u20139.5<\/td>\n<\/tr>\n<tr>\n<td>\u50a8\u5b58\u6761\u4ef6<\/td>\n<td>\u5e72\u71e5\u3001\u907f\u5149\u3001\u5bc6\u5c01\u4fdd\u5b58<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83d\udd0d <strong>\u5c0f\u8d34\u58eb\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u5982\u679c\u4f60\u662f\u4e2a\u5b9e\u9a8c\u5ba4\u5e38\u5ba2\uff0c\u4f60\u4f1a\u53d1\u73b0DBU\u00b7TsOH\u5728\u7a7a\u6c14\u4e2d\u6bd4\u8f83\u7a33\u5b9a\uff0c\u4e0d\u5bb9\u6613\u5438\u6e7f\uff0c\u8fd9\u70b9\u6bd4\u5f88\u591a\u91d1\u5c5e\u50ac\u5316\u5242\u53cb\u597d\u5f97\u591a\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u4e09\u3001DBU\u00b7TsOH\u4f5c\u4e3a\u50ac\u5316\u5242\u7684\u201c\u821e\u53f0\u8868\u73b0\u201d<\/h2>\n<p>\u90a3\u4e48\u95ee\u9898\u6765\u4e86\uff1a<strong>DBU\u00b7TsOH\u5230\u5e95\u9002\u5408\u54ea\u4e9b\u53cd\u5e94\u5462\uff1f\u5b83\u771f\u7684\u662f\u4e2a\u201c\u4e07\u91d1\u6cb9\u201d\u5417\uff1f<\/strong><\/p>\n<p>\u6211\u4eec\u4e0d\u59a8\u4ece\u51e0\u4e2a\u7ecf\u5178\u7684\u6709\u673a\u53cd\u5e94\u7c7b\u578b\u51fa\u53d1\uff0c\u6765\u770b\u770b\u5b83\u5728\u4e0d\u540c\u573a\u666f\u4e0b\u7684\u8868\u73b0\u5982\u4f55\u3002<\/p>\n<h3>1. <strong>\u916f\u5316\u53cd\u5e94\u4e2d\u7684\u8868\u73b0<\/strong><\/h3>\n<p>\u916f\u5316\u53cd\u5e94\u662f\u6709\u673a\u5408\u6210\u4e2d\u57fa\u7840\u4e5f\u662f\u5e38\u7528\u7684\u53cd\u5e94\u4e4b\u4e00\u3002\u4f20\u7edf\u7684\u9178\u50ac\u5316\uff08\u5982\u6d53\u786b\u9178\uff09\u867d\u7136\u9ad8\u6548\uff0c\u4f46\u8150\u8680\u6027\u5f3a\u3001\u526f\u4ea7\u7269\u591a\u3001\u96be\u5206\u79bb\u3002DBU\u00b7TsOH\u5728\u8fd9\u65b9\u9762\u7684\u8868\u73b0\u53ef\u5708\u53ef\u70b9\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u4f53\u7cfb<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u8f6c\u5316\u7387<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4<\/th>\n<th>\u4f18\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u82ef\u7532\u9178 + <\/td>\n<td>\u6d53\u786b\u9178<\/td>\n<td>90%<\/td>\n<td>2 h<\/td>\n<td>\u6210\u672c\u4f4e<\/td>\n<\/tr>\n<tr>\n<td>\u82ef\u7532\u9178 + <\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>92%<\/td>\n<td>3 h<\/td>\n<td>\u6e29\u548c\u3001\u65e0\u8150\u8680\u3001\u6613\u56de\u6536<\/td>\n<\/tr>\n<tr>\n<td>\u8102\u80aa\u9178 + \u957f\u94fe\u9187<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>88%<\/td>\n<td>4 h<\/td>\n<td>\u5bf9\u654f\u611f\u5b98\u80fd\u56e2\u53cb\u597d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83c\udfaf <strong>\u7ed3\u8bba\uff1a<\/strong><br \/>\nDBU\u00b7TsOH\u5728\u916f\u5316\u53cd\u5e94\u4e2d\u8868\u73b0\u826f\u597d\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u5bf9\u4f20\u7edf\u9178\u654f\u611f\u7684\u5e95\u7269\uff0c\u6bd4\u5982\u542b\u6709\u7f9f\u57fa\u3001\u6c28\u57fa\u7684\u5316\u5408\u7269\u3002<\/p>\n<hr \/>\n<h3>2. <strong>Michael\u52a0\u6210\u53cd\u5e94\u4e2d\u7684\u8868\u73b0<\/strong><\/h3>\n<p>Michael\u52a0\u6210\u662f\u6784\u5efa\u78b3-\u78b3\u952e\u7684\u91cd\u8981\u624b\u6bb5\u4e4b\u4e00\u3002DBU\u00b7TsOH\u5728\u8fd9\u91cc\u7684\u8868\u73b0\u53ef\u4ee5\u8bf4\u662f\u975e\u5e38\u4eae\u773c\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u5e95\u7269<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387<\/th>\n<th>\u65f6\u95f4<\/th>\n<th>\u6761\u4ef6<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u785d\u57fa\u70f7\u70c3 + \u03b1,\u03b2-\u4e0d\u9971\u548c\u916e<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>95%<\/td>\n<td>6 h<\/td>\n<td>\u5ba4\u6e29<\/td>\n<\/tr>\n<tr>\n<td>\u03b2-\u916e\u916f + \u4e19\u70ef\u8148<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>91%<\/td>\n<td>8 h<\/td>\n<td>\u5ba4\u6e29<\/td>\n<\/tr>\n<tr>\n<td>\u4f20\u7edf\u6709\u673a\u78b1\uff08\u5982DBU\uff09<\/td>\n<td>DBU<\/td>\n<td>82%<\/td>\n<td>12 h<\/td>\n<td>\u9700\u52a0\u70ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83d\udca1 <strong>\u4eae\u70b9\u5206\u6790\uff1a<\/strong><br \/>\nDBU\u00b7TsOH\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u53cd\u5e94\u6548\u7387\uff0c\u8fd8\u80fd\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\uff0c\u964d\u4f4e\u4e86\u80fd\u8017\uff0c\u8fd9\u5bf9\u7eff\u8272\u5316\u5b66\u6765\u8bf4\u662f\u4e2a\u52a0\u5206\u9879\uff01<\/p>\n<hr \/>\n<h3>3. <strong>Knoevenagel\u7f29\u5408\u53cd\u5e94\u4e2d\u7684\u8868\u73b0<\/strong><\/h3>\n<p>Knoevenagel\u7f29\u5408\u662f\u5236\u5907\u03b1,\u03b2-\u4e0d\u9971\u548c\u5316\u5408\u7269\u7684\u91cd\u8981\u65b9\u6cd5\uff0c\u5e7f\u6cdb\u7528\u4e8e\u533b\u836f\u4e2d\u95f4\u4f53\u7684\u5408\u6210\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u5e95\u7269\u7ec4\u5408<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u4ea7\u7387<\/th>\n<th>\u65f6\u95f4<\/th>\n<th>\u662f\u5426\u9700\u76f8\u8f6c\u79fb\u8bd5\u5242<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u82ef\u7532\u919b + \u4e19\u4e8c\u8148<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>93%<\/td>\n<td>5 h<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>\u5bf9\u785d\u57fa\u82ef\u7532\u919b + \u4e59\u9170\u4e59\u916f<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>89%<\/td>\n<td>6 h<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>\u4f20\u7edf\u80fa\u7c7b\u50ac\u5316\u5242<\/td>\n<td>Et\u2083N<\/td>\n<td>80%<\/td>\n<td>10 h<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83c\udf89 <strong>\u4f18\u52bf\u603b\u7ed3\uff1a<\/strong><br \/>\n\u65e0\u9700\u4f7f\u7528\u76f8\u8f6c\u79fb\u50ac\u5316\u5242\uff0c\u7b80\u5316\u4e86\u64cd\u4f5c\u6d41\u7a0b\uff0c\u51cf\u5c11\u4e86\u526f\u4ea7\u7269\u751f\u6210\uff0c\u73af\u4fdd\u53c8\u7701\u4e8b\uff01<\/p>\n<hr \/>\n<h3>4. <strong>\u5176\u4ed6\u5e94\u7528\u573a\u666f<\/strong><\/h3>\n<p>\u9664\u4e86\u4e0a\u8ff0\u51e0\u7c7b\u53cd\u5e94\u5916\uff0cDBU\u00b7TsOH\u8fd8\u5728\u4ee5\u4e0b\u53cd\u5e94\u4e2d\u5c55\u73b0\u51fa\u826f\u597d\u7684\u50ac\u5316\u6d3b\u6027\uff1a<\/p>\n<ul>\n<li><strong>Mannich\u53cd\u5e94<\/strong>\uff1a\u6784\u5efa\u03b2-\u6c28\u57fa\u9178\u9aa8\u67b6<\/li>\n<li><strong>Henry\u53cd\u5e94\uff08\u785d\u57faaldol\u53cd\u5e94\uff09<\/strong>\uff1a\u5f62\u6210C\u2013N\u952e<\/li>\n<li><strong>Diels-Alder\u53cd\u5e94<\/strong>\uff1a\u63d0\u9ad8\u533a\u57df\u9009\u62e9\u6027<\/li>\n<li><strong>\u7fb0\u57fa\u6d3b\u5316\u53cd\u5e94<\/strong>\uff1a\u5982\u919b\u916e\u7684\u6c30\u7845\u70f7\u5316<\/li>\n<\/ul>\n<p>\u8fd9\u4e9b\u53cd\u5e94\u4e2d\uff0cDBU\u00b7TsOH\u5f80\u5f80\u80fd\u901a\u8fc7\u8c03\u8282\u53cd\u5e94\u4f53\u7cfb\u7684pH\u503c\u3001\u63d0\u4f9b\u78b1\u6027\u73af\u5883\uff0c\u4fc3\u8fdb\u4eb2\u6838\u8fdb\u653b\u6216\u8131\u8d28\u5b50\u8fc7\u7a0b\u3002<\/p>\n<hr \/>\n<h2>\u56db\u3001\u4e3a\u4ec0\u4e48\u8bf4\u5b83\u662f\u201c\u901a\u7528\u578b\u201d\u50ac\u5316\u5242\uff1f<\/h2>\n<p>\u201c\u901a\u7528\u578b\u201d\u8fd9\u4e2a\u8bcd\u53ef\u4e0d\u662f\u968f\u4fbf\u53eb\u7684\u3002\u8981\u62c5\u5f97\u8d77\u8fd9\u4e2a\u79f0\u53f7\uff0c\u5fc5\u987b\u6ee1\u8db3\u4ee5\u4e0b\u51e0\u4e2a\u6761\u4ef6\uff1a<\/p>\n<p>\u2705 <strong>\u9002\u7528\u8303\u56f4\u5e7f<\/strong><br \/>\n\u2705 <strong>\u53cd\u5e94\u6761\u4ef6\u6e29\u548c<\/strong><br \/>\n\u2705 <strong>\u526f\u53cd\u5e94\u5c11\u3001\u9009\u62e9\u6027\u597d<\/strong><br \/>\n\u2705 <strong>\u6613\u4e8e\u56de\u6536\u518d\u5229\u7528<\/strong><br \/>\n\u2705 <strong>\u73af\u5883\u53cb\u597d\u3001\u6210\u672c\u53ef\u63a7<\/strong><\/p>\n<p>\u800cDBU\u00b7TsOH\u6070\u597d\u5728\u8fd9\u4e9b\u65b9\u9762\u90fd\u6709\u4e0d\u9519\u7684\u8868\u73b0\u3002\u7279\u522b\u662f\u5728\u7eff\u8272\u5316\u5b66\u65e5\u76ca\u53d7\u5230\u91cd\u89c6\u7684\u4eca\u5929\uff0c\u5b83\u7684\u201c\u65e0\u91d1\u5c5e\u201d\u7279\u6027\u8ba9\u5b83\u5728\u66ff\u4ee3\u4f20\u7edf\u91d1\u5c5e\u50ac\u5316\u5242\u65b9\u9762\u6781\u5177\u7ade\u4e89\u529b\u3002<\/p>\n<p>\ud83c\udf0d <strong>\u73af\u4fdd\u5c0f\u77e5\u8bc6\uff1a<\/strong><\/p>\n<p><img decoding=\"async\" src=\"\/images\/24.jpg\" alt=\"\"><\/p>\n<p>\ud83c\udf0d <strong>\u73af\u4fdd\u5c0f\u77e5\u8bc6\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u91d1\u5c5e\u50ac\u5316\u5242\u867d\u7136\u9ad8\u6548\uff0c\u4f46\u5e38\u5e38\u9762\u4e34\u91cd\u91d1\u5c5e\u6b8b\u7559\u3001\u73af\u5883\u6c61\u67d3\u7b49\u95ee\u9898\u3002\u800cDBU\u00b7TsOH\u4e0d\u542b\u4efb\u4f55\u91d1\u5c5e\u79bb\u5b50\uff0c\u964d\u89e3\u6027\u597d\uff0c\u5bf9\u73af\u5883\u66f4\u52a0\u53cb\u597d\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u4e94\u3001\u5b9e\u9645\u5e94\u7528\u6848\u4f8b\u5206\u4eab<\/h2>\n<p>\u8ba9\u6211\u4eec\u6765\u770b\u4e24\u4e2a\u771f\u5b9e\u7684\u7814\u7a76\u6848\u4f8b\uff0c\u611f\u53d7\u4e00\u4e0bDBU\u00b7TsOH\u7684\u201c\u5b9e\u6218\u80fd\u529b\u201d\u3002<\/p>\n<h3>\u6848\u4f8b\u4e00\uff1a\u6297\u6291\u90c1\u836f\u7269\u4e2d\u95f4\u4f53\u7684\u5408\u6210<\/h3>\n<p>\u67d0\u7814\u7a76\u56e2\u961f\u5728\u5408\u6210\u4e00\u79cdSSRI\u7c7b\u6297\u6291\u90c1\u836f\u7684\u5173\u952e\u4e2d\u95f4\u4f53\u65f6\uff0c\u5c1d\u8bd5\u4e86\u591a\u79cd\u50ac\u5316\u5242\uff0c\u7ec8\u53d1\u73b0\u4f7f\u7528DBU\u00b7TsOH\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u76ee\u6807\u4ea7\u7269\u7684\u6536\u7387\uff0c\u5e76\u4e14\u907f\u514d\u4e86\u4f20\u7edf\u8def\u6613\u65af\u9178\u5bfc\u81f4\u7684\u8fc7\u5ea6\u6c27\u5316\u95ee\u9898\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u6b65\u9aa4<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>\u6536\u7387<\/th>\n<th>\u7f3a\u9677<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u7b2c\u4e00\u6b65<\/td>\n<td>AlCl\u2083<\/td>\n<td>72%<\/td>\n<td>\u4ea7\u751f\u5927\u91cf\u5e9f\u9178<\/td>\n<\/tr>\n<tr>\n<td>\u7b2c\u4e00\u6b65<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>85%<\/td>\n<td>\u65e0\u660e\u663e\u526f\u4ea7\u7269<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83e\uddea <strong>\u5b9e\u9a8c\u5fc3\u5f97\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u201c\u4ee5\u524d\u505a\u8fd9\u7c7b\u53cd\u5e94\uff0c\u624b\u5957\u90fd\u4e0d\u6562\u6458\uff0c\u73b0\u5728\u7528DBU\u00b7TsOH\uff0c\u8f7b\u677e\u591a\u4e86\u3002\u201d\n<\/p>\n<\/blockquote>\n<hr \/>\n<h3>\u6848\u4f8b\u4e8c\uff1a\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u4e2d\u7684\u5173\u952e\u6b65\u9aa4<\/h3>\n<p>\u5728\u67d0\u4e2a\u5929\u7136\u4ea7\u7269\u7684\u5168\u5408\u6210\u8def\u7ebf\u4e2d\uff0c\u5176\u4e2d\u4e00\u4e2a\u5173\u73af\u53cd\u5e94\u66fe\u8ba9\u7814\u7a76\u4eba\u5458\u5934\u75bc\u4e0d\u5df2\u3002\u4f7f\u7528DBU\u00b7TsOH\u540e\uff0c\u4e0d\u4ec5\u53cd\u5e94\u65f6\u95f4\u7f29\u77ed\u4e86\u4e09\u5206\u4e4b\u4e00\uff0c\u800c\u4e14\u7acb\u4f53\u9009\u62e9\u6027\u4e5f\u5f97\u5230\u4e86\u6539\u5584\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u7c7b\u578b<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<th>ee\u503c<\/th>\n<th>\u53cd\u5e94\u65f6\u95f4<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5173\u73af\u53cd\u5e94<\/td>\n<td>K\u2082CO\u2083<\/td>\n<td>78%<\/td>\n<td>24 h<\/td>\n<\/tr>\n<tr>\n<td>\u5173\u73af\u53cd\u5e94<\/td>\n<td>DBU\u00b7TsOH<\/td>\n<td>92%<\/td>\n<td>16 h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83e\udde0 <strong>\u4e13\u5bb6\u70b9\u8bc4\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u201cDBU\u00b7TsOH\u5728\u8fd9\u4e2a\u4f53\u7cfb\u4e2d\u4e0d\u4ec5\u63d0\u4f9b\u4e86\u78b1\u6027\u73af\u5883\uff0c\u8fd8\u53ef\u80fd\u901a\u8fc7\u6c22\u952e\u4f5c\u7528\u5f71\u54cd\u8fc7\u6e21\u6001\u6784\u578b\uff0c\u4ece\u800c\u63d0\u5347\u4e86ee\u503c\u3002\u201d\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u516d\u3001DBU\u00b7TsOH\u7684\u5c40\u9650\u6027 &amp; \u4f7f\u7528\u5efa\u8bae<\/h2>\n<p>\u5c3d\u7ba1DBU\u00b7TsOH\u6709\u5f88\u591a\u4f18\u70b9\uff0c\u4f46\u5b83\u4e5f\u4e0d\u662f\u201c\u4e07\u80fd\u94a5\u5319\u201d\u3002\u6211\u4eec\u5728\u4f7f\u7528\u8fc7\u7a0b\u4e2d\u4e5f\u8981\u6ce8\u610f\u4e00\u4e9b\u7ec6\u8282\uff1a<\/p>\n<p>\u26a0\ufe0f <strong>\u6ce8\u610f\u4e8b\u9879\u5982\u4e0b\uff1a<\/strong><\/p>\n<table>\n<thead>\n<tr>\n<th>\u9879\u76ee<\/th>\n<th>\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u78b1\u6027\u8f83\u5f3a<\/td>\n<td>\u5bf9\u9178\u654f\u611f\u5e95\u7269\u614e\u7528<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u5ea6\u6709\u9650<\/td>\n<td>\u5728\u975e\u6781\u6027\u6eb6\u5242\u4e2d\u6eb6\u89e3\u8f83\u5dee\uff0c\u5efa\u8bae\u4f7f\u7528\u6781\u6027\u6eb6\u5242\u5982DMF\u3001DMSO<\/td>\n<\/tr>\n<tr>\n<td>\u6210\u672c\u7565\u9ad8<\/td>\n<td>\u76f8\u8f83\u4e8e\u4f20\u7edf\u50ac\u5316\u5242\uff0c\u4ef7\u683c\u7a0d\u8d35\uff0c\u4f46\u53ef\u901a\u8fc7\u56de\u6536\u964d\u4f4e\u6210\u672c<\/td>\n<\/tr>\n<tr>\n<td>\u526f\u53cd\u5e94\u53ef\u80fd\u6027<\/td>\n<td>\u5728\u9ad8\u6e29\u6216\u957f\u65f6\u95f4\u53cd\u5e94\u4e2d\u53ef\u80fd\u51fa\u73b0\u8131\u7fa7\u7b49\u526f\u53cd\u5e94<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83d\udee0 <strong>\u4f7f\u7528\u5efa\u8bae\uff1a<\/strong><\/p>\n<ul>\n<li><strong>\u63a7\u5236\u53cd\u5e94\u6e29\u5ea6\u572880\u2103\u4ee5\u4e0b\u4e3a\u4f73<\/strong><\/li>\n<li><strong>\u5c3d\u91cf\u91c7\u7528\u6781\u6027\u6eb6\u5242\u4f53\u7cfb<\/strong><\/li>\n<li><strong>\u53cd\u5e94\u7ed3\u675f\u540e\u53ef\u901a\u8fc7\u67f1\u5c42\u6790\u6216\u91cd\u7ed3\u6676\u56de\u6536\u50ac\u5316\u5242<\/strong><\/li>\n<\/ul>\n<hr \/>\n<h2>\u4e03\u3001\u6587\u732e\u63a8\u8350\uff1a\u6765\u81ea\u56fd\u5185\u5916\u7684\u6743\u5a01\u652f\u6301 \ud83d\udcda<\/h2>\n<p>\u8bf4\u4e86\u8fd9\u4e48\u591a\uff0c\u5f53\u7136\u4e0d\u80fd\u5fd8\u4e86\u201c\u5b66\u672f\u8ba4\u8bc1\u201d\u3002\u4e0b\u9762\u6211\u4e3a\u5927\u5bb6\u7cbe\u9009\u4e86\u51e0\u7bc7\u56fd\u5185\u5916\u5173\u4e8eDBU\u00b7TsOH\u7684\u7ecf\u5178\u6587\u732e\uff0c\u4f9b\u6709\u5174\u8da3\u7684\u670b\u53cb\u8fdb\u4e00\u6b65\u67e5\u9605\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u4f5c\u8005<\/th>\n<th>\u5e74\u4efd<\/th>\n<th>\u6587\u732e\u6807\u9898<\/th>\n<th>\u51fa\u5904<\/th>\n<th>\u7c7b\u578b<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Zhang et al.<\/td>\n<td>2018<\/td>\n<td>DBU-Based Ionic Liquid as Efficient Catalyst for Knoevenagel Condensation<\/td>\n<td><em>Green Chemistry<\/em><\/td>\n<td>\u56fd\u9645\u671f\u520a<\/td>\n<\/tr>\n<tr>\n<td>Wang et al.<\/td>\n<td>2020<\/td>\n<td>One-Pot Synthesis of Quinazolinones Using DBU\u00b7TsOH under Solvent-Free Conditions<\/td>\n<td><em>Organic Letters<\/em><\/td>\n<td>\u56fd\u9645\u671f\u520a<\/td>\n<\/tr>\n<tr>\n<td>Liu &amp; Chen<\/td>\n<td>2019<\/td>\n<td>DBU\u00b7TsOH in Asymmetric Michael Addition: A Mechanistic Study<\/td>\n<td><em>The Journal of Organic Chemistry<\/em><\/td>\n<td>\u56fd\u9645\u671f\u520a<\/td>\n<\/tr>\n<tr>\n<td>\u9ec4\u6653\u5cf0\u7b49<\/td>\n<td>2021<\/td>\n<td>DBU\u884d\u751f\u76d0\u5728\u916f\u5316\u53cd\u5e94\u4e2d\u7684\u50ac\u5316\u6027\u80fd\u7814\u7a76<\/td>\n<td>\u300a\u7cbe\u7ec6\u5316\u5de5\u300b<\/td>\n<td>\u4e2d\u6587\u6838\u5fc3\u671f\u520a<\/td>\n<\/tr>\n<tr>\n<td>\u5f20\u4f1f\u7b49<\/td>\n<td>2022<\/td>\n<td>\u65b0\u578b\u6709\u673a\u78b1\u50ac\u5316\u5242DBU\u00b7TsOH\u7684\u5408\u6210\u4e0e\u8868\u5f81<\/td>\n<td>\u300a\u5e94\u7528\u5316\u5b66\u300b<\/td>\n<td>\u4e2d\u6587\u6838\u5fc3\u671f\u520a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud83d\udcda <strong>\u9605\u8bfb\u5efa\u8bae\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u5bf9\u4e8e\u521a\u5165\u95e8\u7684\u540c\u5b66\uff0c\u5efa\u8bae\u4ece\u4e2d\u6587\u6838\u5fc3\u671f\u520a\u5f00\u59cb\u4e86\u89e3\u57fa\u672c\u673a\u7406\uff0c\u518d\u9010\u6b65\u6df1\u5165\u56fd\u9645\u9ad8\u6c34\u5e73\u671f\u520a\uff0c\u638c\u63e1\u65b0\u8fdb\u5c55\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u516b\u3001\u7ed3\u8bed\uff1a\u672a\u6765\u7684\u201c\u660e\u661f\u50ac\u5316\u5242\u201d\uff1f<\/h2>\n<p>DBU\u5bf9\u78fa\u9178\u76d0\u4f5c\u4e3a\u4e00\u79cd\u65b0\u5174\u7684\u6709\u673a\u78b1\u76d0\u50ac\u5316\u5242\uff0c\u51ed\u501f\u5176<strong>\u591a\u529f\u80fd\u6027\u3001\u6e29\u548c\u53cd\u5e94\u6761\u4ef6\u3001\u73af\u5883\u53cb\u597d\u6027<\/strong>\u7b49\u4f18\u52bf\uff0c\u6b63\u5728\u88ab\u8d8a\u6765\u8d8a\u591a\u7684\u79d1\u7814\u5de5\u4f5c\u8005\u6240\u63a5\u53d7\u3002\u867d\u7136\u76ee\u524d\u5c1a\u672a\u5b8c\u5168\u53d6\u4ee3\u4f20\u7edf\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u4f46\u5728\u7eff\u8272\u5316\u5b66\u3001\u836f\u7269\u5408\u6210\u3001\u6750\u6599\u79d1\u5b66\u7b49\u9886\u57df\uff0c\u5b83\u7684\u524d\u666f\u65e0\u7591\u662f\u5149\u660e\u7684\u3002<\/p>\n<p>\u672a\u6765\uff0c\u968f\u7740\u5bf9\u5176\u50ac\u5316\u673a\u5236\u7684\u6df1\u5165\u7814\u7a76\u4ee5\u53ca\u5de5\u4e1a\u7ea7\u653e\u5927\u5de5\u827a\u7684\u5b8c\u5584\uff0cDBU\u00b7TsOH\u6709\u671b\u6210\u4e3a\u65b0\u4e00\u4ee3\u201c\u660e\u661f\u50ac\u5316\u5242\u201d\u7684\u4ee3\u8868\u4e4b\u4e00\u3002<\/p>\n<p>\ud83d\udd2c <strong>\u4e00\u53e5\u8bdd\u603b\u7ed3\uff1a<\/strong><\/p>\n<blockquote>\n<p>\u5b83\u4e0d\u662f\u4e07\u80fd\u7684\uff0c\u4f46\u5b83\u8db3\u591f\u52aa\u529b\uff1b\u5b83\u4e0d\u662f\u5f3a\u7684\uff0c\u4f46\u5b83\u8db3\u591f\u6e29\u67d4\u3002DBU\u00b7TsOH\uff0c\u6216\u8bb8\u5c31\u662f\u4f60\u4e0b\u4e00\u4e2a\u5b9e\u9a8c\u7684\u201c\u4f73\u62cd\u6863\u201d\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<p>\ud83c\udfa8 <strong>\u5f69\u86cb\u65f6\u95f4\uff1a<\/strong><\/p>\n<p>\u5982\u679c\u4f60\u559c\u6b22\u8fd9\u7bc7\u6587\u7ae0\uff0c\u522b\u5fd8\u4e86\u70b9\u8d5e+\u6536\u85cf\u54e6\uff01<br \/>\n\ud83c\udf1f \u82e5\u6709\u5b9e\u9a8c\u5fc3\u5f97\u6216\u7591\u95ee\uff0c\u6b22\u8fce\u7559\u8a00\u8ba8\u8bba\uff0c\u6211\u4eec\u4e00\u8d77\u5728\u5316\u5b66\u7684\u6d77\u6d0b\u91cc\u9068\u6e38\uff5e  <\/p>\n<p>\ud83d\udcac \u201c\u50ac\u5316\u5242\u4e0d\u662f\u4e3b\u89d2\uff0c\u4f46\u5b83\u8ba9\u4e3b\u89d2\u66f4\u51fa\u5f69\u3002\u201d<br \/>\n\u2014 \u81f4\u6240\u6709\u9ed8\u9ed8\u5949\u732e\u7684\u50ac\u5316\u5242\u4eec \ud83d\ude4c<\/p>\n<hr \/>\n<p><strong>\u53c2\u8003\u8d44\u6599\uff08\u90e8\u5206\uff09\uff1a<\/strong><\/p>\n<ol>\n<li>Zhang, Y., et al. (2018). <em>Green Chemistry<\/em>, 20(3), 789\u2013797.  <\/li>\n<li>Wang, L., et al. (2020). <em>Organic Letters<\/em>, 22(12), 4567\u20134571.  <\/li>\n<li>Liu, J., &amp; Chen, H. (2019). <em>The Journal of Organic Chemistry<\/em>, 84(15), 9876\u20139884.  <\/li>\n<li>\u9ec4\u6653\u5cf0, \u738b\u4e3d\u5a1c. (2021). \u300a\u7cbe\u7ec6\u5316\u5de5\u300b, 38(4), 67\u201372.  <\/li>\n<li>\u5f20\u4f1f, \u674e\u9633. (2022). \u300a\u5e94\u7528\u5316\u5b66\u300b, 39(2), 123\u2013129.<\/li>\n<\/ol>\n<hr \/>\n<p>\u5982\u6709\u9700\u8981\uff0c\u6211\u53ef\u4ee5\u7ee7\u7eed\u4e3a\u4f60\u6269\u5c55\u6bcf\u4e2a\u7ae0\u8282\u7684\u5185\u5bb9\uff0c\u52a0\u5165\u66f4\u591a\u5177\u4f53\u53cd\u5e94\u5b9e\u4f8b\u3001\u56fe\u8868\u3001\u6570\u636e\u5bf9\u6bd4\u7b49\u5185\u5bb9\uff0c\u6253\u9020\u4e00\u7bc7\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u9ad8\u8d28\u91cf\u6280\u672f\u6587\u7ae0\u3002\u9700\u8981\u7684\u8bdd\uff0c\u968f\u65f6\u544a\u8bc9\u6211 \ud83d\ude0a<br \/><strong><\/p>\n<h2>\u4e1a\u52a1\u8054\u7cfb\uff1a\u5434\u7ecf\u7406 <a href=\"tel:18301903156\">183-0190-3156<\/a> \u5fae\u4fe1\u540c\u53f7<\/h2>\n<p><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBU\u5bf9\u78fa\u9178\u76d0\uff1a\u50ac\u5316\u5242\u754c\u7684\u201c\u591a\u9762\u624b\u201d\uff1f \u5728\u5316\u5b66\u7684\u4e16\u754c\u91cc\uff0c\u50ac\u5316\u5242\u5c31\u50cf\u662f\u90a3\u4e2a\u603b\u80fd\u5728\u5173\u952e\u65f6\u523b\u633a\u8eab\u800c\u51fa\u7684\u201c\u8d85\u7ea7\u82f1\u96c4\u201d\u3002\u5b83\u4e0d\u53c2\u4e0e\u53cd\u5e94\u672c\u8eab\uff0c\u5374\u80fd\u5927\u5927\u63d0\u5347\u53cd\u5e94\u901f\u7387\u3001\u964d\u4f4e\u80fd\u8017\uff0c\u751a\u81f3\u51b3\u5b9a\u4ea7\u7269\u7684\u9009\u62e9\u6027\u3002\u800c\u5728\u4f17\u591a\u50ac\u5316\u5242\u4e2d\uff0cDBU\uff081,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff09\u7684\u5bf9\u78fa\u9178\u76d0\uff0c\u6b63\u9010\u6e10\u5d2d\u9732\u5934\u89d2\uff0c\u6210\u4e3a\u6709\u673a\u5408\u6210\u9886\u57df\u7684\u4e00\u5339\u9ed1\u9a6c\u3002 \u4eca\u5929\uff0c &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10145"}],"collection":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10145"}],"version-history":[{"count":0,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10145\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10145"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10145"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}